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Patients who received steroids (prednisone equivalent >10 mg) during anti-pd1 therapy were divided into two main cohorts based on the duration of steroid administration of ≤2 weeks or >2 weeks. Time to disease progression, overall response, and overall survival were assessed. Often the dose is then slowly reduced to a lower daily dose that keeps symptoms away. The length of treatment can vary, depending on the disease. Sometimes the steroid treatment is gradually stopped if the condition improves. However, steroids are needed for life for some conditions, as symptoms return if the steroids are stopped. For example, steroids, like dexamethasone, may be prescribed to control nausea and vomiting from chemotherapy and can also make you feel energized (and cause difficulty sleeping). Hence, it is helpful to avoid taking steroids after five or six o'clock in the evening. The treatment of infectious diseases with steroids is a little bit complicated because the infection can cause injury. The host response to infection can cause tissue injury
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